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Friday, February 23 • 8:00am - 12:00pm
282 Regulatory T-Cells (Tregs) Within Bone Marrow-Derived Stem Cells (BMSCs) Actively Confer Immunomodulatory and Neuroprotective Effects Against Stroke

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Elliot G. Neal, MS/BSE; Sandra A. Acosta, PhD; Yuji Kaneko, PhD; Cesar V. Borlongan, PhD

In the present study, we investigated BMSCs for the presence T_regs, and found a distinct subpopulation of CD4^+/CD25^+/FoxP3^+ T_regs.  We found that the neuroprotective effect of T_regs and BMSCs in co-culture varied in a ratio-dependent manner. We found that T_regs were capable of minimizing stem cell production of IL-6, a pro-inflammatory cytokine and that increasing the concentration of T_regs inhibits BMSC secretion of FGF-b, a cytokine related to BMSC proliferation and differentiation.  We showed the ratio of T_regs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.


Elliot George Neal, MS/BSE

Med II student, Morsani College of Medicine

Friday February 23, 2018 8:00am - 12:00pm