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Friday, February 23 • 8:00am - 12:00pm
202 Retrospective evaluation of flow cytometry and gene rearrangement analysis of blood and skin biopsies in patients with suspected cutaneous T-cell lymphoma

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Julie D. Gibbs, MD; Lucia Seminario, MD, PhD; Elizabeth Sagatys, MD; Jane Messina, MD

Cutaneous T-cell lymphoma (CTCL) accounts for 80-85% of all primary cutaneous lymphoma (PCL), and mycosis fungoides is most common, comprising nearly 50% of PCL. Timely definitive diagnosis is essential for appropriate clinical management of CTCL. Ancillary studies such as T-cell receptor gene rearrangement (TCRGR) and flow cytometry (FC) of tissue and blood can augment histopathologic evaluation in confirming a clonal lymphocytic population, yet the value of these studies in early or suspected CTCL has not been systematically investigated. We performed an IRB-approved retrospective chart review of 30 consecutive patients presenting to a cutaneous lymphoma clinic for evaluation of suspected or recurrent CTCL, to evaluate the sensitivity of TCRGR (beta and gamma genes) and FC (analyzing a 10 marker T cell panel) using clinicopathologic diagnosis of mycosis fungoides as the gold standard.


Julie Gibbs

Fellow, Morsani College of Medicine

Friday February 23, 2018 8:00am - 12:00pm