Jamie E. Meegan, Xiaoyuan (Sherry) Yang, Melanie Jannaway, Victor Chatterjee, Sarah Y. Yuan
Circulating extracellular histones are known to contribute to tissue injury in systemic inflammatory responses to infection, trauma, and burns. Citrullination of histone 3, catalyzed by the peptidylarginine deiminase 4 (PAD4) enzyme, is thought to initiate the process of NETosis (the release of neutrophil extracellular traps) in response to infection. NETs are composed of a chromatin web with attached proteases and histones, including citrullinated histone 3 (citH3). This study aimed to identify the effects of citH3 on endothelial barrier dysfunction during inflammation.
