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Friday, February 23 • 8:00am - 12:00pm
143 Mechanism of Treatment-induced Drug Resistance in Lung Cancer

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Mark Howel, Ryan Green, Elspeth Foran, Rajesh Nair, Stanley Stevens, Jit Banerjee, Shyam Mohapatra, and Subhra Mohapatra

Drug resistance is common in NSCLC patients receiving treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs). To investigate the development of this drug resistance, our lab has developed EGFR TKI resistant human lung cancer cell lines. Preliminary data has revealed that upregulation of 2 proteins that may be causing enhanced EGFR downstream signaling, possibly outcompeting the effects of the inhibitor and leading to resistance.


Mark C Howell

Doctoral student, Morsani College of Medicine

Friday February 23, 2018 8:00am - 12:00pm